SYNTHESIS OF ALTISSIMACOUMARIN D AND OTHER PRENYLATED COUMARINS AND THEIR ABILITY TO REVERSE THE MULTIDRUG RESISTANCE PHENOTYPE IN CANDIDA ALBICANS

Synthesis of Altissimacoumarin D and Other Prenylated Coumarins and Their Ability to Reverse the Multidrug Resistance Phenotype in Candida albicans

Azoles are the main antifungal agents employed in clinical practice to treat invasive candidiasis.Nonetheless, their efficacy is limited by fungal resistance mechanisms, mainly the overexpression of efflux pumps.Consequently, candidiasis has a worrisome death rate of 75%.One potential strategy to overcome efflux-mediated resistance is to g35 coupe

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Legal nihilism in resolving family conflicts of nobles and peasants of Russian Empire in the first third of XIX century

The article highlights the ways of resolving family conflicts nobles and peasants in the first third of the XIX century in the Russian Empire, against the background of the ongoing systematization of legislation.Based on examination of the letters and memoirs of the nobles and peasants we highlighted the methods, which are actually used to solve fa

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Functional Ingredients from Agri-Food Waste: Effect of Inclusion Thereof on Phenolic Compound Content and Bioaccessibility in Bakery Products

Reducing food loss and waste is among the efforts to relieve the pressure on natural resources and move towards more sustainable food systems.Alternative pathways of food waste management include valorization of by-products as a source of phenolic compounds for formulation of functional foods.Bakery products may act as an optimal copyright of pheno

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